A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer’s disease
Dr Steven Cunane has developed a PET scan for ketones. This can demonstrate areas of the brain where ketones are uptaken and being used, this can be compared to a glucose PET Scan and in Alzheimers disease this can show big differences and demonstrates a mechanism how ketones and the Ketogenic diet can help with Alzheimers patients
Deteriorating brain glucose metabolism precedes the clinical onset of Alzheimer’s disease (AD) and appears to contribute to its etiology. Ketone bodies, mainly β-hydroxybutyrate and acetoacetate, are the primary alternative brain fuel to glucose. Some reports suggest that brain ketone metabolism is unchanged in AD but, to our knowledge, no such data are available for MCI.